Endocrine Abstracts

Introduction: Acromegaly is a chronic endocrine disorder caused by excess growth hormone (GH) secretion. Hypersecretion of GH causes increased IGF-1 secretion from the liver which in turn leads to a series of multisystemic complications including somatic overgrowth and multiple comorbidities.Case report: Thirty-nine-year-old female patient was seen in ophthalmology outpatient clinic with the complaint of a mass inside the right upper eyelid. On ophthalmo...

Mitogen-activated protein kinases (MAPK) are a family of serine/threonine kinases and are key signaling pathways involved in the regulation of normal cell proliferation, survival and differentiation. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated protein kinases (ERK1 and 2); c-Jun N-terminal kinases (JNK1-3); p38s (α, β, γ, δ) and ERK5. Aberrant regulation of MAPK cascades contribute to cancer and ...

A 71-year-old hypertensive and diabetic male patient was seen in the outpatient clinic for routine control. On laboratory examination his serum potassium level was 5.76 mmol/l and serum sodium level was 135 mmol/l. Control serum potassium level was 5.7 mmol/l. In past medical history he was prescribed telmisartan/hydrochlorothiazide combination (80 mg/12.5 mg) 1 month ago for treatment of hypertension. His other medications included nifedipine, fluvastatin sodium, aspirin, pio...